Animal models of Middle East respiratory syndrome coronavirus infection
Identifieur interne : 001893 ( Main/Exploration ); précédent : 001892; suivant : 001894Animal models of Middle East respiratory syndrome coronavirus infection
Auteurs : Neeltje Van Doremalen ; Vincent J. MunsterSource :
- Antiviral Research [ 0166-3542 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Callithrix, Coronavirus du syndrome respiratoire du Moyen-Orient, Cricetinae, Dipeptidyl peptidase 4 (génétique), Encéphale (anatomopathologie), Encéphale (virologie), Femelle, Humains, Infections à coronavirus (virologie), Macaca mulatta, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Souris, Souris transgéniques.
- MESH :
- anatomopathologie : Encéphale, Poumon.
- génétique : Dipeptidyl peptidase 4.
- virologie : Encéphale, Infections à coronavirus, Poumon.
- Animaux, Callithrix, Coronavirus du syndrome respiratoire du Moyen-Orient, Cricetinae, Femelle, Humains, Macaca mulatta, Modèles animaux de maladie humaine, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Brain (pathology), Brain (virology), Callithrix, Coronavirus Infections (virology), Cricetinae, Dipeptidyl Peptidase 4 (genetics), Disease Models, Animal, Female, Humans, Lung (pathology), Lung (virology), Macaca mulatta, Mice, Mice, Transgenic, Middle East Respiratory Syndrome Coronavirus.
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- pathology : Brain, Lung.
- virology : Brain, Coronavirus Infections, Lung.
- Animals, Callithrix, Cricetinae, Disease Models, Animal, Female, Humans, Macaca mulatta, Mice, Mice, Transgenic, Middle East Respiratory Syndrome Coronavirus.
Abstract
MERS-CoV has infected >1100 patients to date, with an associated case fatality rate of approximately 40%. Animals ranging from mice to rabbits to nonhuman primates have been inoculated with MERS-CoV, with varying outcomes. Mice expressing human DPP4 are susceptible to infection and develop severe disease. Rhesus macaques and marmosets are also susceptible, but marmosets develop more severe disease. Further development of appropriate animal models to conduct medical countermeasure research is a public health priority.
Url:
DOI: 10.1016/j.antiviral.2015.07.005
PubMed: 26192750
PubMed Central: 4561025
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Animal models of Middle East respiratory syndrome coronavirus infection</title><author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. 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Munster</name></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (pathology)</term><term>Brain (virology)</term><term>Callithrix</term><term>Coronavirus Infections (virology)</term><term>Cricetinae</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Macaca mulatta</term><term>Mice</term><term>Mice, Transgenic</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Callithrix</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cricetinae</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Encéphale (anatomopathologie)</term><term>Encéphale (virologie)</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Souris</term><term>Souris transgéniques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Encéphale</term><term>Infections à coronavirus</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Callithrix</term><term>Cricetinae</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Macaca mulatta</term><term>Mice</term><term>Mice, Transgenic</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Callithrix</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cricetinae</term><term>Femelle</term><term>Humains</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">MERS-CoV has infected >1100 patients to date, with an associated case fatality rate of approximately 40%.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">Animals ranging from mice to rabbits to nonhuman primates have been inoculated with MERS-CoV, with varying outcomes.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">Mice expressing human DPP4 are susceptible to infection and develop severe disease.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">Rhesus macaques and marmosets are also susceptible, but marmosets develop more severe disease.</p></list-item><list-item id="o0025"><label>•</label><p id="p0025">Further development of appropriate animal models to conduct medical countermeasure research is a public health priority.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adney, D R" uniqKey="Adney D">D.R. 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Munster</name><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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